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PHENBUTEROL introduces a new development in advanced fat burning technology through the activation of Uncoupling Protein 1 (UCP-1). UCP-1 enhances fat burning in brown adipose tissue (BAT) by shuttling fatty acids from stored body fat into the mitochondria to generate heat and trigger thermogenesis. Utilizing fatty acids from stored body fat, rather than ATP from muscle tissue, is a unique fat burning mechanism of UCP-1 and brown adipose tissue – and one of the key fat burning actions and benefits of PHENBUTEROL.
To optimize the fat burning potential of UCP-1 and BAT, in the development of PHENBUTEROL MuscleMeds researchers explored the key mechanisms of action and identified some newly discovered highly standardized natural compounds. One of their key finding was a potent clinically researched compound called 6-Paradol. This compound is derived from a plant native to West Africa called Grains of Paradise, and it has been show in clinical studies to upregulate UCP-1. Other naturally derived compounds such as hordenine, octopamine, synepherine, llex paraguariensis and Rouwolfia serpentia provide synergistic fat burning effects. In addition, these select active ingredients in PHENBUTEROL also exert powerful energizing and mood enhancing effects to take the edge off dieting. PHENBUTEROL is a potent fat burning catalyst for serious athletes looking to lose excess body fat quickly and effectively.
NOTE: PHENBUTEROL is a trade name and is not intended to depict any comparison to any pharmaceutical or other product or any particular benefit thereof.
This is the first fat burning supplement targeting the activation of UCP-1 and BAT from MuscleMeds.
Since BAT tissue is activated through Beta 1, 2 and 3 (and to some extent Alpha) adrenergic receptors and is highly activated by norepinephrine, a unique combination of ingredients was assembled to maximize the fat burning potential of BAT by activating several receptors. In addition, ingredients were chosen for their potential to stimulate norepinephrine, which acts on Beta-3 and is by far the most potent activator of BAT.
THE SCIENCE OF UCP-1 THERMOGENESIS
Uncoupling Protein 1:
Uncoupling Protein 1 (aka UCP-1) is a protein known to be required for a specific fat cell’s heat-generating capabilities. Originally coined “Thermogenin,” UCP-1 is used by specific tissues to generate heat via non-shivering thermogenesis, which is the primary means of heat generation in certain mammals (hibernating mammals for example) and in human infants. The name was originally used to describe an oxidative process for energy generation not coupled to ATP synthesis. 15
UCP-1 is a mitochondrial transport protein found within the inner membrane of mitochondria in all mammals and in plants. Mitochondria themselves are organelles within cells where respiration occurs. In this case, respiration refers to the process by which a cell obtains energy from organic compounds. In other words, the burning of a fuel source to generate heat. Or more simply put, thermogenesis.1
The citric acid cycle, fatty acid oxidation and gluconeogenesis are other actions that also take place within mitochondria. The energy produced by respiration within the mitochondria is used for ATP synthesis via oxidative phosphorylation. What is unique about UCP-1 is that it can cause a rapid, uncoupled respiration that does not rely upon ATP synthesis, rather it shuttles fatty acids into the cell to burn with an end result of heat generation. In other words, UCP-1 is the equivalent of a “regulated uncoupler” that can control heat production. 1
UCP-1 works by decreasing the proton gradient thereby increasing the permeability of the inner mitochondrial membrane. It is thought that with this reduced gradient/increased permeability; protons can grab fatty acids and pour them into the cell to burn. Not all cells contain UCP-1. In fact, it is unique to a specific tissue, sometimes referred to as an organ, called Brown Adipose Tissue (BAT). The rate of metabolism in all tissues, other than BAT, is determined by utilization of ATP. UCPI and BAT are unique in that they do not follow this same metabolic pathway. The physiological action of UCP-1 on BAT can be called “unrestrained oxidation of fuels with the sole byproduct being the generation of heat.” 12
Take 1 capsule daily. Do not exceed recommended dose.
Importeur: Prometeus NL Maxwellstraat 297825 GA Emmen The Netherlands