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Hydrapharm Alchemy 60 Kapseln

  • SW12769
  • 60 Stück (0,83 € * / 1 Stück)
59,90 € * (16.69% gespart)
49,90 € *

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Hydrapharm Alchemy 60 Kapseln günstig auf supp-shop.de kaufen und bestellen 

The Strongest AI ever released

Alchemy is very versatile delivering muscle and performance gains alongside fat loss. It is ideal for men seeking to optimise their endocrine profile by boosting natural testosterone and simultaneously reducing estrogen.

Warum ALchemy?

Alchemy was carefully engineered to fulfill a single purpose: To inhibit aromatase as strongly as possible, so that estrogen levels decline dramatically and rapidly. The endocrine shift Alchemy elicits will not only help to prevent the estrogenic side-effects of androgens, it'll eliminate water-retention, increase free testosterone, and improve your performance at the gym.

Einnahmezeitpunkt=

Alchemy is an extremely potent aromatase inhibitor, the strongest non-hormonal supplement class there is. As such, it should be used in cycles of 4-8 weeks with 4 weeks off before commencing use again.

Für wen geeignet?

Alchemy is very versatile delivering muscle and performance gains alongside fat loss. It is ideal for men seeking to optimise their endocrine profile by boosting natural testosterone and simultaneously reducing estrogen.

Hydrapharm have waited a long time to release a new supplement. As a company devoted to introducing only the very best, state of the art supplements on the market it has taken a long time to produce a follow up to the phenomenally successful Adamantine, a muscle builder with incredible recovery enhancing properties, that has become one of the best selling supplements ever at Predator Nutrition.

With Alchemy, Hydrapharm have once again produced a product with no peers. Quite simply, they have introduced something to the market with ingredients that have never been seen before in sports nutrition but which has huge promise based on extensive scientific research. Here is what they have to say on Alchemy.

Hydrapharm Alchemy Description

Alchemy contains Flavozole -- a flavan derivative which is structurally similar to epicatechin, naringenin, and related compounds. Flavans such as Flavozole are ubiquitous throughout nature and are commonly found in tea and chocolate.

But Flavozole is unique. It is, simply put, the most potent AI that the supplement world has ever seen. Studies have demonstrated tremendous inhibitory potency (IC50 = 41nm) at human placental aromatase [1], which is a staggering 127x (!) more potent than aminogluthemide (brand name Cytadren) and is also significantly more potent than that old standby, formestane. In effect, we've rendered every other AI obsolete.

Alchemy also contains dehydroabiatic acid, a potent natural AI isolated from the resin of commiphora myrrha. Although nearly 10x less potent than Flavozole, there were many very good reasons for its inclusion:

  • It reduces inflammation in adipose tissue [2] and in macrophages [3] and may therefore assist with both weight loss and with the joint pain associated with low estrogen levels.

  • A reduction in adipose tissue inflammation should reduce aromatase gene espression. [4]

  • It should possess a different pharmacokinetic profile and a different rate of cellular distribution and uptake when compared to Flavozole. The combination of the two agents should therefore help ensure that estrogen levels decline quickly and remain low.

  • It's a potent glucose-disposal agent [2], which should help shuttle glucose into muscle cells.

  • It directly activates SIRT1 [5], which has anti-aging effects, and increases insulin sensitivity in skeletal muscle.

  • Naringenin is a mild aromatase inhibitor. Its inclusion in Alchemy is due to the fact that it has recently been identified as a ligand for human sex-hormone binding globulin (SHBG). [6,7]

  • Naringenin is the only small natural molecule which binds to SHBG with high affinity & is capable of displacing natural steroids at physiological concentrations. Therefore, when it binds to SHBG, it displaces testosterone and estradiol, resulting in high free concentrations of those hormones. With the aforementioned two ingredients having driven estradiol levels into the ground, naringenin serves primarily to boost levels of free, bioavailable testosterone.

NUTRITION

Hydrapharm Alchemy 60 capsules
Serving Size: 1 capsule
Servings per container: 60
  Amount Per Serving  
7-hydroxy-4-imidazolyl-flavan 7mg  
Dehydroabiatic acid 40mg  
Naringenin 40mg  
 
Other ingredients: Gelatin, Rice Flour, Magnesium Stearate

DIRECTIONS FOR USE

Take one to two capsules daily. Take with food, preferably at lunch and dinnertime.

1. Pouget C, Fagnere C, Basly JP, Habrioux G, Chulia AJ. Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition. Bioorg Med Chem Lett. 2002;12(20):2859-61.
2.  Kang MS, Hirai S, Goto T, et al. Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK-Ay mice. Biofactors. 2009;35(5):442-8.
3. Kang MS, Hirai S, Goto T, et al. Dehydroabietic acid, a phytochemical, acts as ligand for PPARs in macrophages and adipocytes to regulate inflammation. Biochem Biophys Res Commun. 2008;369(2):333-8.
4. Polari L, Yatkin E, Martínez chacón MG, et al. Weight gain and inflammation regulate aromatase expression in male adipose tissue, as evidenced by reporter gene activity. Mol Cell Endocrinol. 2015;412:123-30.
5. Kim J, Kang YG, Lee JY, et al. The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1. Mol Cell Endocrinol. 2015;412:216-25.
6. Déchaud H, Ravard C, Claustrat F, De la perrière AB, Pugeat M. Xenoestrogen interaction with human sex hormone-binding globulin (hSHBG). Steroids. 1999;64(5):328-34.
7. Hodgert Jury H, Zacharewski TR, Hammond GL. Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands. J Steroid Biochem Mol Biol. 2000;75(2-3):167-76.

 

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